ABSTRACT
The aim of this study was to define the electrocardiogram [ECG] changes following the moderate to severe CO intoxication in rats, and also evaluating the effect of erythropoietin [EPO] on observed cardiac disturbances. The growing literature on erythropoietin effect on cardiac ischemia led us to question its effect on cardiotoxicity due to the carbon monoxide poisoning. Wistar rats were exposed to three different concentrations of CO [250 PPM, 1000 PPM or 3000 PPM]. EPO was administrated [5000 IU/Kg, intraperitoneal injection] at the end of CO exposure and then the animals were re-oxygenated with ambient air. Subsequently ECG recording, heart rate and carboxyhemoglobin values were evaluated. ECG changes following the CO intoxication included ST segment elevation and depression, T wave inversion and first-degree AV block. Ischemic ECG changes reduced significantly in EPO-treated animals. In the present study, for the first time, EPO was investigated for the management of cardiac complications due to the CO poisoning. Our results showed that EPO could inhibit ischemic changes of ECG after the CO poisoning
Subject(s)
Animals, Laboratory , Electrocardiography , Erythropoietin/pharmacology , Rats, Wistar , Carbon Monoxide Poisoning/physiopathologyABSTRACT
Many people are poisoned by carbon monoxide [CO] with potentially devastating outcomes. CO is the leading cause of fatal poisoning in the industrialized world as well as being endemic in many parts of the developing world. CO poisoning is a serious threat that people need to get informed about. Diagnosis can be difficult because, the early symptoms are quite nonspecific, resemble those of influenza, motion sickness or heat exhaustion, and are often misinterpreted. Those suffering from CO poisoning may initially complain of vague symptoms but the symptoms can rapidly progress to coma and even death, so called silent death. It is therefore critical that CO be eliminated from the body as soon and quickly as possible. Unless patient dies, recovery occurs as CO is removed from the circulation, accelerated by breathing O[2]
Subject(s)
Humans , Carbon Monoxide Poisoning/physiopathology , Carbon Monoxide Poisoning/therapy , Environmental Pollution , Hyperbaric OxygenationABSTRACT
La intoxicación por monóxido de carbono (CO), constituye un problema de alta mortalidad. En Estados Unidos alrededor de 10.000 personas pierden al menos 1 día de trabajo debido a una intoxicación por CO, y se produce alrededor de 3.000 muertes al año por esta causa. La incidencia de intoxicación por CO en nuestro país no es bien conocida, debido en parte a que es una condición subdiagnosticada, sin embargo estaría dentro de las primeras causas de intoxicación en la población general. En los últimos años esta intoxicación ha despertado mayor preocupación y difusión por medios periodísticos, por lo que se han adoptado medidas de fiscalización más rigurosas
Subject(s)
Humans , Male , Female , Carbon Monoxide Poisoning/physiopathology , Blood Gas Analysis , Carboxyhemoglobin/analysis , Carbon Monoxide Poisoning/therapy , Oximetry/statistics & numerical dataSubject(s)
Humans , Animals , Dogs , Rabbits , Rats , Tobacco , Myocardium/ultrastructure , Oxygen Consumption/drug effects , Carbon Monoxide Poisoning/physiopathology , Environmental Pollution/adverse effects , Arteriosclerosis Obliterans/etiology , Cholesterol/blood , Myoglobin/metabolism , Myocardial Infarction/etiology , Carbon Monoxide/metabolismABSTRACT
Of 32 cases suffering from acute carbon monoxide (CO) poisoning brainstem auditory evoked potential (BAEP) abnormalities were exhibited in 8 cases. the abnormalities of BAEPs could be divided into two patterns: a peripheral pattern (6 cases) of prolongation of latency to wave 1 without prolongation of interpeak latency, and a central pattern (2 cases) of prolongation of latencies to all waves and interpeak latencies. The indicence of BAEP abnormality tended to increase in accordance with an unconscious duration of more than 24 hours; during acute CO poisoning. A BAEP abnormality exhibiting a peripheral pattern usually returned to normal within one month after anoxia, but cases showing central pattern of BAEP abnormality died during acute anoxic insult due to the possible involvement of the brainstem. Thus, BAEPs can be used for evaluating the functional intergrity of the auditory pathways and for providing prognostic values in acute CO poisoning.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Acute Disease , Basal Ganglia/diagnostic imaging , Brain Stem/physiopathology , Carbon Monoxide Poisoning/physiopathology , Evoked Potentials, Auditory , Middle Aged , Tomography, X-Ray ComputedABSTRACT
A 36-year-old man was brought unconscious to the emergency room; he suffered anoxic brain damage due to carbon monoxide (CO) intoxication, and had decerebrate rigidity clinically and died 1 month later after the acute insult. Computed tomography with contrast enhancement failed to show a brainstem lesion but the brainstem auditory evoked potential (BAEP) demonstrated the brainstem involvement. The BAEP can be used as an objective diagnostic aid for evaluating brainstem lesions in CO intoxication.